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The demonstration that the oxidative stress associated with mycotoxins can be related to direct suppression of GCLC gene function, post-translational modification of Nrf2 or the presence of excess TGF- suggests that the lack of glutathione may be due to the inability of mycotoxin-affected cells to adequately form glutathione

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Lupus appears in neither document

In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later

This method is particularly beneficial for individuals who have tried oral supplements without noticeable improvement

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